This report provides general guidelines in the structural design of blast resistant petrochemical facilities. Informational coverage is provided for OSHA requirements, design objectives, siting considerations, and load determination with references mentioned for more detailed information. More detailed coverage is provided for types of construction, dynamic material strengths, allowable response criteria, analysis methods, and design procedures. Typical details and ancillary considerations, such as doors and windows, are also included. A "how to" discussion on the upgrade of existing buildings is provided for older facilities which may not meet current needs. Three example calculations are included to illustrate design procedures.